Teruna J. Siahaan

Teruna Siahaan
  • Aya and Takeru Higuchi Distinguished Professor
  • Associate Chair, Pharmaceutical Chemistry; Director, Center for Global Health, School of Pharmacy
  • Member, Executive Committee, School of Pharmacy
  • School of Pharmacy , Pharmaceutical Chemistry

Contact Info

Phone:
785-864-7327
Simons Biosciences Research Laboratories 258
Lawrence
2095 Constant Avenue
Lawrence, KS 66045

Biography —

Dr. Siahaan is the Aya & Takeru Higuchi Distinguished Professor and Associate Chair of the Department of Pharmaceutical Chemistry, The University of Kansas. He earned his Ph.D. degree in Organic Chemistry from the University of Arizona in 1986 to study carbanion chemistry. He did postdoctoral research at UC Santa Barbara in the area of total synthesis of a natural product antibiotic that has a cyclic peptide alkaloid structure. Then, he moved to La Jolla Cancer Research Foundation from 1987–1989 (currently Burnham Institute), working to design cyclic RGD peptides and peptidomimetics as inhibitors of cell adhesion during tumor metastasis and thrombosis. Following that, he joined Sterling Winthrop Pharmaceutical Company (1989–1991) to work on using peptide libraries to search for optimal substrates for various matrix metalloproteases (MMPs); these substrates were then converted to peptidomimetics to inhibit MMPs for suppressing tumor metastasis and rheumatoid arthritis in animal models. In 1991, Dr. Siahaan joined the Department of Pharmaceutical Chemistry at The University of Kansas as an Assistant Professor and moved up through the ranks to Distinguished Professor in 2016. He published 180 peer-reviewed papers, 22 book chapters, 12 minor communications, 2 edited books, and 13 patents. Dr. Siahaan serves as a member of the Executive and Tenure Committee of the School of Pharmacy, The University of Kansas since 2006. Dr. Siahaan served as the Program Director of the T32 NIH Biotechnology Training Program at The University of Kansas in 2009¬–2019. The Biotechnology Training Program is aimed at training predoctoral students to work in the development of therapeutic agents and vaccines such as peptides, proteins, and oligonucleotides derived from biotechnology research. Over the past 28 years, he has mentored numerous undergraduate students, graduate students, postdoctoral fellows, and visiting scholars. These students and scholars are currently working in pharmaceutical industries, academia, and government research institutes in the US and other countries. He is also interested in and actively participates in recruiting and enhancing the number of underrepresented graduate students to the graduate programs, specifically in the School of Pharmacy and in The University of Kansas in general. Dr. Siahaan is a Fellow of the American Association of Pharmaceutical Scientists (AAPS). He also received honors and awards, including Department of Chemistry Fellowship, The University of Arizona (1984); Clark W. Smith Fellowship, The University of Arizona (1985); Self Faculty Scholar, The University of Kansas (2001–2004); Eurand Honorable Mention Award, Controlled Release Society (2002); Pfizer Research Scholar Award (2002–2004); J. Clarence Karcher Lecturer, University of Oklahoma (2005); 2013 Mentor of the Year, Office for Diversity in Science Training, The University of Kansas; and 2014 PhRMA Foundation Award in Excellence in Pharmaceutics.

Education —

Postdoctoral Fellow, Total Synthesis of Cyclic Peptide Alkaloid Antibiotic, University of California Santa Barbara
Ph.D. in Organic Chemistry, University of Arizona
M.S. in Organic Chemistry, University of Indonesia
B.S. in Chemistry, University of Indonesia

Research —

Professor Siahaan's research interests are in the utilization and modulation of cell adhesion molecules on the cell surface for enhancing drug permeation through the intestinal mucosa and blood-brain barrier (BBB) and for targeted drug delivery to a specific immune cell type for controlling autoimmune diseases. Dr. Siahaan’s group is using cadherin peptides to enhance permeation of large hydrophilic molecules (i.e., peptides and proteins) through the intestinal mucosa and BBB. The hypothesis is that E-cadherin peptides modulate the E-cadherin interactions in at the intercellular junctions in a reversible and equilibrium fashion to create larger openings that will allow paracellular permeation of large hydrophilic molecules (e.g., peptides and proteins). This method has successfully been used to deliver small molecule drug and neurotrophic protein into the brains of brain disease animal models such as medulloblastoma brain tumor, multiple sclerosis, and Alzheimer’s disease. His group is also using peptides derived from cell adhesion molecules (i.e., ICAM-1 and LFA-1) to target drugs to leukocytes and vascular endothelial cells in inflammatory and autoimmune diseases (i.e., multiple sclerosis, type-1 diabetes, and rheumatoid arthritis). Cell adhesion peptides and proteins are being used to target antigenic peptides in bifunctional peptide inhibitor (BPI) and I-domain antigen conjugate (IDAC) to block the formation of the immunological synapse at the interface between T cells and antigen-presenting cells (APC). BPI and IDAC molecules have been shown to suppress autoimmune diseases in models for multiple sclerosis (MS), type-1 diabetes (T1D), and rheumatoid arthritis (RA).

Research interests:

  • Brain Delivery
  • Antigen-specific Immune Suppression
  • Peptide and Protein Delivery to the brain
  • Delivering drug to immune cells.

Teaching —

Professor Siahaan is coordinating and teaching an undergraduate course, PHCH 518: Physical-Chemical Principles of Solution Dosage Forms. The objective of this class is to train students to recognize the effect drug physicochemical properties in solution formulations. The lectures cover a) thermodynamic properties of solution, b) effects of physicochemical properties (i.e., structure, charges) and solution properties (e.g., pH, temperature, buffer, ionic strength and colligative properties) on drug solubility, c) kinetics and mechanisms of drug degradation in solution, and d) mechanism of drug absorption and bioavailability.

Professor Siahaan is also coordinating and teaching a graduated course, PHCH 870: Advanced Pharmaceutical Biotechnology. The objective of this course is to introduce the students to the discovery, development and production of pharmaceutical proteins and vaccines. In the discovery section, the role of structure in governing protein activity, specificity and stability particularly for pharmaceutically important proteins will be covered. Physical and spectroscopic methods for analysis of protein structure will be described. Degradation processes, both chemical and physical, which are peculiar to proteins will be presented, as well as strategies designed to prevent them. Introduction to recombinant DNA technology, large-scale production, purification, and isolation procedures used for recombinant proteins in the pharmaceutical industry will be covered in the development and production sections. Recent topics on basic principles of vaccine discovery and developments including vaccine formulation, manufacturing, cold chain delivery, and analysis will also be discussed. Procedures for handling regulatory guidelines (filing NDA's and IND's) will also be addressed.

Teaching interests:

  • Solution Dosage Forms
  • Drug Physicochemical Properties
  • Peptides and Protein Formulations
  • Peptide and Protein Stability.

Selected Publications —

Ulapane, K R, B M Kopec, M EG Moral, and T J Siahaan. “Peptides and Drug Delivery.” Book Chapters. In Adv Exp Med Biol, 1030:167-184. Springer, 2017.

Moral, Mario E.G., and Teruna J. Siahaan. “Conjugates of Cell Adhesion Peptides for Therapeutics and Diagnostics Against Cancer and Autoimmune Diseases.” Reviews. Curr. Top. Med. Chem. Betham Science, July 22, 2017.

Ulapane, K. R., N. On, P. Kiptoo, T. D. Williams, D. W. Miller, and T. J. Siahaan. “Improving Brain Delivery of Biomolecules via BBB Modulation in Mouse and Rat: Detection Using MRI, NIRF, and Mass Spectrometry.” Journal Articles. Nanotheranostics 1, no. 2 (May 8, 2017): 217–231.

Kuehl, C, S Thati, B Sullivan, J Sestak, M Thompson, T Siahaan, and C Berkland. “Pulmonary Administration of Soluble Antigen Arrays Is Superior to Antigen in Treatment of Experimental Autoimmune Encephalomyelitis.” Journal Articles. J. Pharm. Sci., May 30, 2017.

White, D., Z. Khedri, P. Kiptoo, T. J. Siahaan, and T. J. Tolbert. “Synthesis of a Bifunctional Peptide Inhibitor-IgG1 Fc Fusion That Suppresses Experimental Autoimmune Encephalomyelitis.” Journal Articles. Bioconjugate Chemistry 28 (May 5, 2017): 1867–1877.

Obi, A. T., E. Andraska, Y. Kanthi, C. W. Kessinger, Y. M. Elfline, C. Luke, T. J. Siahaan, F. A. Jaffer, T. W. Wakefield, and P. K. Henke. “Endotoxaemia-Augmented Murine Venous Thrombosis Is Dependent on TLR-4 and ICAM-1, and Potentiated by Neutropenia.” Journal Articles. Thromb. Haemost. 117, no. 2 (January 26, 2017): 339–348.

Alaofi, A., E. Farokhi, V. D. Prasasty, A. Anbanandam, K. Kuczera, and T. J. Siahaan. “Probing the Interaction between CHAVc3 Peptide and the EC1 Domain of E-Cadherin Using NMR and Molecular Dynamics Simulations.” Journal Articles. J. Biomol. Struct. Dyn. 35, no. 1 (January 10, 2017): 92–104.

Mahzoon, S., T. J. Siahaan, and M. S. Detamore. “Functionalizing With Bioactive Peptides to Generate Bio-Instructive Scaffold. (Chapter 2).” Book Chapters. In Bio-Instructive Scaffolds for Musculoskeletal Tissue Engineering and Regenerative Medicine, edited by J. Brown, S. Kumbar, and B. Banik, 2016.

Obi, A. T., E. Andraska, Y. Kanthi , C. E. Luke , M. Elfline , S. Madathilparambil, T. J. Siahaan , et al. “Gram-Negative Pneumonia Alters Large-Vein Cell-Adhesion Molecule Profile and Potentiates Experimental Stasis Venous Thrombosis.” Journal Articles. J. Vasc. Res. 53 (September 22, 2016): 186–195.

Büyüktimkin, B., J. Stewart Jr., K. Tabanor, P. Kiptoo, and T. J. Siahaan. “Development of Therapeutic Protein and Peptide Conjugates to Make Better Drugs. (Chapter 20).” Book Chapters. In Drug Delivery: Principles and Applications, edited by B. Wang, L. Hu, and T. J. Siahaan, 475–502. New York: John Wiley & Sons, 2016.

Wang, B., L. Hu, and T Siahaan J, eds. Drug Delivery: Principles and Applications. Books, 2016.

Kiptoo, P., A. M. Calcagno, and T. J. Siahaan. “Physiological, Biochemical, and Chemical Barriers to Drug Delivery. (Chapter 2).” Book Chapters. In Drug Delivery: Principles and Applications, edited by B. Wang, L. Hu, and T. J. Siahaan, 19–32. New York: John Wiley & Sons, 2016.

Alaofi, A., N. On, P. Kiptoo, T. D. Williams, D. W. Miller, and T. J. Siahaan. “Comparison of Linear and Cyclic HAV Peptides in Modulating the Blood-Brain Barrier Permeability: Impact on Delivery of Molecules to the Brain.” Journal Articles. J. Pharm. Sci. 105, no. 2 (February 2016): 797–807.

Tabanor, K., P. Lee, P. Kiptoo, I. Y. Choi, E. B. Sherry, C. S. Eagle, T. D. Williams, and T. J. Siahaan. “Brain Delivery of Drug and MRI Contrast Agent: Detection and Quantitative Determination of Brain Deposition of CPT-Glu Using LC-MS/MS and Gd-DTPA Using Magnetic Resonance Imaging.” Journal Articles. Mol. Pharm., January 6, 2016.

Badawi, A. H., P. Kiptoo, and T. J. Siahaan. “Immune Tolerance Induction against Experimental Autoimmune Encephalomyelitis (EAE) Using a New PLP-B7AP Conjugate That Simultaneously Targets B7/CD28 Costimulatory Signal and TCR/MHC-II Signal.” Journal Articles. J. Multiple Sclerosis 2, no. 1 (November 1, 2015).

Mathaes, R., G. Winter, T. J. Siahaan, A. Besheer, and J. Engert. “Influence of Particle Size, an Elongated Particle Geometry, and Adjuvants on Dendritic Cell Activation.” Journal Articles. Eur. J. Pharm. Biopharm. 94 (July 1, 2015): 542–49.

Prasasty, V. D., M. E. Krause, U. S. Tambunan, A. Anbanandam, J. S. Laurence, and T. J. Siahaan. “(1)H, (13)C and (15)N Backbone Assignment of the EC-1 Domain of Human E-Cadherin.” Journal Articles. Biomol. NMR Assign. 9, no. 1 (April 1, 2015): 31–35.

Laksitorini, M. D., P. K. Kiptoo, N. H. On, J. A. Thliveris, D. W. Miller, and T. J. Siahaan. “Modulation of Intercellular Junctions by Cyclic-ADT Peptides as a Method to Reversibly Increase Blood-Brain Barrier Permeability.” Journal Articles. J. Pharm. Sci. 104, no. 3 (March 1, 2015): 1065–1075.

Stewart, J., A. H. Badawi, P. Kiptoo, and T. J. Siahaan. “Vaccine-like Administration of PLP-PEG-B7AP and MOG-PEG-B7AP to Control EAE in Relapse-Remission and Chronic Progressive Animal Models of Multiple Sclerosis.” Journal Articles. Oligos & Peptides-Chemica Oggi, Chemistry Today 3341–47 (2015): 41–47.

Büyüktimkin, B., P. Kiptoo, and T. J. Siahaan. “Bifunctional Peptide Inhibitors Suppress Interleukin-6 Proliferation and Ameliorates Murine Collagen-Induced Arthritis.” Journal Articles. J. Clin. Cell. Immunol. 5, no. 6 (November 1, 2014).

Thati, S., C. Kuehl, B. Hartwell, J. Sestak, T. J. Siahaan, M. L. Forrest, and C. Berkland. “Routes of Administration and Dose Optimization of Soluble Antigen Arrays in Mice with Experimental Autoimmune Encephalomyelitis.” Journal Articles. J. Pharm. Sci. 104, no. 2 (November 1, 2014): 714–721.

Northrup, L., J. O. Sestak, B. P. Sullivan, S. Thati, B. L. Hartwell, T. J. Siahaan, C. M. Vines, and C. Berkland. “Co-Delivery of Autoantigen and B7 Pathway Modulators Suppresses Experimental Autoimmune Encephalomyelitis.” Journal Articles. The AAPS Journal 16, no. 6 (October 1, 2014): 1204–13.

Sestak, J. O., A. Fakhari, A. H. Badawi, T. J. Siahaan, and C Berkland. “Structure, Size, and Solubility of Antigen Arrays Determines Efficacy in Experimental Autoimmune Encephalomyelitis.” Journal Articles. The AAPS Journal 16, no. 6 (October 1, 2014): 1185–93.

Laksitorini, M., V. D. Prasasty, P. K. Kiptoo, and T. J. Siahaan. “Pathways and Progress in Improving Drug Delivery through the Intestinal Mucosa and Blood-Brain Barriers.” Journal Articles. Therapeutic Delivery 5, no. 10 (September 1, 2014): 1143–1163.

Prasasty, Vivitri  D., Usman S.F. Tambunan, and Teruna J. Siahaan. “Homology Modeling and Molecular Dynamics Studies of EC1 Domain of VE-Cadherin to Elucidate Docking Interaction with Cadherin-Derived Peptide.” Journal Articles. OnLine Journal of Biological Sciences 14, no. 2 (May 25, 2014): 155–62.

Sestak, J. O., B. Sullivan, S. Thati, L. Northrup, B. Hartwell, L. Antunez, L. Forrest, T. J. Siahaan, and C. Berkland. “Codelivery of Antigen and an Immune Cell Adhesion Inhibitor Is Necessary for Efficacy of Soluble Antigen Arrays in Experimental Encephalomyelitis.” Journal Articles. Molecular Therapy — Methods & Clinical Development 1 (April 9, 2014): 14008.

On, N. H., P. Kiptoo, T. J. Siahaan, and D W Miller. “Modulation of Blood-Brain Barrier Permeability in Mice Using Synthetic E-Cadherin Peptide.” Journal Articles. Molecular Pharmaceutics 11, no. 3 (March 3, 2014): 974–981.

Chittasupho, C., J. Sestak, L. Shannon, T. J. Siahaan, C. M. Vines, and C Berkland. “Hyaluronic Acid Graft Polymers Displaying Peptide Antigen Modulate Dendritic Cell Response in Vitro.” Journal Articles. Mol. Pharm. 11, no. 1 (January 6, 2014): 367–373.

Badawi, A. H., and T. J. Siahaan. “Suppression of MOG- and PLP-Induced Experimental Autoimmune Encephalomyelitis Using a Novel Multivalent Bifunctional Peptide Inhibitor.” Journal Articles. J. Neuroimmunol. 263, no. 1–2 (September 15, 2013): 20–27.

Sestak, J., M. Mullins, L. Northrup, S. Thati, M. L. Forrest, T. J. Siahaan, and C. Berkland. “Single-Step Grafting of Aminooxy-Peptides to Hyaluronan: A Simple Approach to Multifunctional Therapeutics for Experimental Autoimmune Encephalomyelitis.” Journal Articles. J. Control. Rel. 168, no. 3 (May 28, 2013): 334–340.

Kiptoo, P., B. Büyüktimkin, A. H. Badawi, J Stewart, R Ridwan, and T J Siahaan. “Controlling Immune Response and Demyelination Using Highly Potent Bifunctional Peptide Inhibitors in the Suppression of Experimental Autoimmune Encephalomyelitis.” Journal Articles. Clin. Exp. Immunol. 172, no. 1 (April 1, 2013): 23–36.

Phongpradist, R., C. Chittasupho, N. Intasai, T. J. Siahaan, C. J. Berkland, P. Charoenkwan, S. Anuchapreeda, and C. Ampasavate. “Biodegradable Nanoparticles Surface Modification Techniques with CIBR Peptide Targeting to LFA-1 Expressing Leukemic Cells.” Journal Articles. J. Nanotechnol. Eng. Med. 3, no. 4 (March 26, 2013): 041005-1–9.

Büyüktimkin, B., P. Manikwar, P. K. Kiptoo, A. H. Badawi, J. M. Stewart Jr, and T. J. Siahaan. “Vaccinelike and Prophylactic Treatments of EAE with Novel I-Domain Antigen Conjugates (IDAC): Targeting Multiple Antigenic Peptides to APC.” Journal Articles. Mol. Pharm. 10, no. 1 (January 7, 2013): 297–306.

Majumdar, S., M. E. Anderson, C. R. Xu, T. V. Yakovleva, L. C. Gu, T. R. Malefyt, and T. J. Siahaan. “Methotrexate (MTX)-CIBR Conjugate for Targeting MTX to Leukocytes: Conjugate Stability and in Vivo Efficacy in Suppressing Rheumatoid Arthritis.” Journal Articles. Journal of Pharmaceutical Sciences 101, no. 9 (August 1, 2012): 3275–91.

Badawi, A. H., and T. J. Siahaan. “Immune Modulating Peptides for the Treatment and Suppression of Multiple Sclerosis.” Journal Articles. Clin. Immunol. 144, no. 2 (July 1, 2012): 127–38.

Manikwar, P., P. Kiptoo, A. H Badawi, B. Büyüktimkin, and T. J. Siahaan. “Antigen-Specific Blocking of CD4-Specific Immunological Synapse Formation Using BPI and Current Therapies for Autoimmune Diseases.” Journal Articles. Med. Res. Rev. 32, no. 4 (June 1, 2012): 727–764.

Trivedi, M., J. S. Laurence, T. D. Williams, C. R. Middaugh, and T. J. Siahaan. “Improving the Stability of the EC1 Domain of E-Cadherin by Thiol Alkylation of the Cysteine Residue.” Journal Articles. Int. J. Pharm. 431, no. 1–2 (June 15, 2012): 16–25.

Majumdar, S., and T. J. Siahaan. “Peptide-Mediated Targeted Drug Delivery.” Journal Articles. Med. Res. Rev. 32, no. 3 (1, 2012): 637–558.

Büyüktimkin, B., Q. Wang, P. Kiptoo, J. M. Stewart, C. Berkland, and T. J. Siahaan. “Vaccine-like Controlled-Release Delivery of an Immunomodulating Peptide to Treat Experimental Autoimmune Encephalomyelitis.” Journal Articles. Mol. Pharm. 9, no. 4 (April 2, 2012): 979–985.

Manikwar, P., B. Büyüktimkin, P. Kiptoo, A. H. Badawi, N. A. Galeva, T. D. Williams, and T. J. Siahaan. “I-Domain-Antigen Conjugate (IDAC) for Delivering Antigenic Peptides to APC: Synthesis, Characterization, and in Vivo EAE Suppression.” Journal Articles. Bioconjugate Chemistry 23, no. 3 (March 21, 2012): 509–517.

Badawi, A. H., P. Kiptoo, W. T. Wang, I. Y. Choi, P. Lee, C. M. Vines, and T. J. Siahaan. “Suppression of EAE and Prevention of Blood-Brain Barrier Breakdown after Vaccination with Novel Bifunctional Peptide Inhibitor.” Journal Articles. Neuropharmacology 62, no. 4 (March 1, 2012): 1874–81.

Phongpradist, R., S. Chiampanichayakul, S. Tima, T. J. Siahaan, C. J. Berkland, S. Anuchapreeda, and C. Ampasavate. “Potential CIBR-Conjugated PLGA Nanoparticles for Selective Targeting to Leukemic Cells.” Journal Articles. World Acad. of Sci., Eng. Tech. 66 (2012): 202–210.

Chittasupho, C., T. J. Siahaan, C. M. Vines, and C. Berkland. “Autoimmune Therapies Targeting Costimulation and Emerging Trends in Multivalent Therapeutics.” Journal Articles. Therapeutic Delivery 2, no. 7 (June 1, 2011): 873–889.

Manikwar, P., T. Zimmerman, F. J. Blanco, T. D. Williams, and T. J. Siahaan. “Rapid Identification of Fluorochrome Modification Sites in Proteins by LC ESI-Q-TOF Mass Spectrometry.” Journal Articles. Bioconjugate Chemistry 22, no. 7 (June 20, 2011): 1330–13336.

Khondee, S., A. Baoum, T. J. Siahaan, and C. Berkland. “Calcium Condensed LABL-TAT Complexes Effectively Target Gene Delivery to ICAM-1 Expressing Cells.” Journal Articles. Mol. Pharm. 8, no. 3 (May 6, 2011): 788–798.

Fakhari, A., A. Baoum, T. J. Siahaan, K. B. Le , and C. Berkland. “Controlling Ligand Surface Density Optimizes Nanoparticle Binding to ICAM-1.” Journal Articles. J. Pharm. Sci. 100, no. 3 (March 1, 2011): 1045–1056.

Chittasupho, C., L. Shannon, T. J. Siahaan, C. M. Vines, and C. Berkland. “Nanoparticles Targeting Dendritic Cell Surface Molecules Effectively Block T Cell Conjugation and Shift Response.” Journal Articles. ACS Nano 5, no. 3 (March 22, 2011): 1693–702.

Kiptoo, P., E. Sinaga, A. M. Calcagno, H. Zhao, N. Kobayashi, U. S. Tambunan, and T. J. Siahaan. “Enhancement of Drug Absorption through the Blood-Brain Barrier and Inhibition of Intercellular Tight Junction Resealing by E-Cadherin Peptides.” Journal Articles. Mol. Pharm. 8, no. 1 (February 7, 2011): 239–249.

Badawi, A. H., B. Büyüktimkin, P. Kiptoo, and T. J. Siahaan. “Peptides and Proteins for Treatment and Suppression of Type 1 Diabetes. (Chapter 15).” Book Chapters. In Type 1 Diabetes - Pathogenesis, Genetics and Immunotherapy, edited by David Wagner, 339–354. InTech, 2011.

Manikwar, P., B. A. Tejo, H. Shinogle, D. S. Moore, T. Zimmerman, F. Blanco, and T. J. Siahaan. “Utilization of I-Domain of LFA-1 to Target Drug and Marker Molecules to Leukocytes.” Journal Articles. Theranostics 1 (January 1, 2011): 277–289.

Satyanarayanajois, S. D, B. Büyüktimkin, A. Gokhale, S. Ronald, T. J. Siahaan, and J. R. Latendresse. “A Peptide from the Beta-Strand Region of CD2 Protein That Inhibits Cell Adhesion and Suppresses Arthritis in a Mouse Model.” Journal Articles. Chem. Biol. Drug Des. 76, no. 3 (August 1, 2010): 234–244.

Ridwan, R., P. Kiptoo, N. Kobayashi, S. Weir, M. Hughes, T. Williams, R. Soegianto, and T. J. Siahaan. “Antigen-Specific Suppression of Experimental Autoimmune Encephalomyelitis by a Novel Bifunctional Peptide Inhibitor: Structure Optimization and Pharmacokinetics.” Journal Articles. J. Pharmacol. Exp. Ther. 332, no. 3 (March 1, 2010): 1136–1145.

Chittasupho, C., P. Manikwar, J. P. Krise, T. J. Siahaan, and C. Berkland. “CIBR Effectively Targets Nanoparticles to LFA-1 on Acute Lymphoblastic T Cells.” Journal Articles. Molecular Pharmaceutics 7, no. 1 (February 1, 2010): 146–155.

Zhao, H., P. Kiptoo, T. D. Williams, T. J. Siahaan, and E. M. Topp. “Immune Response to Controlled Release of Immunomodulating Peptides in a Murine Experimental Autoimmune Encephalomyelitis (EAE) Model.” Journal Articles. Journal of Controlled Release 141, no. 2 (January 25, 2010): 145–152.

Phongpradist, R., C. Chittasupho, S. Okonogi, T. J. Siahaan, S. Anuchapreeda, C. Amphasavate, and C. Berkland. “LFA-1 on Leukemic Cells as a Target for Therapy or Drug Delivery.” Journal Articles. Curr. Pharm. Des. 16 (2010): 2321–2330.

Trivedi, M. V., J. S. Laurence, and T. J. Siahaan. “The Role of Thiols and Disulfides on Protein Stability.” Journal Articles. Curr. Prot. Pept. Sci. 10, no. 6 (November 1, 2009): 614–625.

Trivedi, M., R. A. Davis, Y. Shabaik, A. Roy, G. Verkhivker, J. S Laurence, C. R. Middaugh, and T. J. Siahaan. “The Role of Covalent Dimerization on the Physical and Chemical Stability of the EC1 Domain of Human E-Cadherin.” Journal Articles. J. Pharm. Sci. 98, no. 10 (September 1, 2009): 3562–3574.

Williams, S. J., Q. Wang, R. R. Macgregor, T. J. Siahaan, L. Stehno-Bittel, and C. Berkland. “Adhesion of Pancreatic Beta Cells to Biopolymer Films.” Journal Articles. Biopolymers 91, no. 8 (July 1, 2009): 676–685.

Tejo, B. A., and T. J. Siahaan. “Solution Structure of a Novel T-Cell Adhesion Inhibitor Derived from the Fragment of ICAM-1 Receptor: Cyclo(1,8)-Cys-Pro-Arg-Gly-Gly-Ser-Val-Cys.” Journal Articles. Biopolymers 91, no. 8 (July 1, 2009): 633–641.

Zheng, K., J. S. Laurence, K. Kuczera, G. Verkhivker, C. R. Middaugh, and T. J. Siahaan. “Characterization of Multiple Stable Conformers of the EC5 Domain of E-Cadherin and the Interaction of EC5 with E-Cadherin Peptides.” Journal Articles. Chem. Biol. Drug Des. 73, no. 6 (May 1, 2009): 584–598.

Chittasupho, C., S. X. Xie, A. Baoum, T. Yakovleva, T. J. Siahaan, and C. J. Berkland. “ICAM-1 Targeting of Doxorubicin-Loaded PLGA Nanoparticles to Lung Epithelial Cells.” Journal Articles. Eur.  J. Pharm. Sci. 37, no. 2 (12, 2009): 141–150.

Majumdar, S., B. A. Tejo, A. H. Badawi, D. Moore, J. P. Krise, and T. J. Siahaan. “Effect of Modification of the Physicochemical Properties of ICAM-1-Derived Peptides on Internalization and Intracellular Distribution in the Human Leukemic Cell Line HL-60.” Journal Articles. Mol. Pharm. 6, no. 2 (March 1, 2009): 396–406.

Zheng, K., C. R. Middaugh, and T. J. Siahaan. “Evaluation of the Physical Stability of the EC5 Domain of E-Cadherin: Effects of PH, Temperature, Ionic Strength, and Disulfide Bonds.” Journal Articles. J. Pharm. Sci. 98, no. 1 (January 1, 2009): 63–73.

Kobayashi, N., P. Kiptoo, H. Kobayashi, R. Ridwan, S. Brocke, and T. J. Siahaan. “Prophylactic and Therapeutic Suppression of Experimental Autoimmune Encephalomyelitis by a Novel Bifunctional Peptide Inhibitor.” Journal Articles. Clin. Immunol. 129, no. 1 (September 1, 2008): 69–79.

Iskandarsyah, B. A. Tejo, U. S. Tambunan, G. Verkhivker, and T. J. Siahaan. “Structural Modifications of ICAM-1 Cyclic Peptides to Improve the Activity to Inhibit Heterotypic Adhesion of T Cells.” Journal Articles. Chem. Biol. Drug Des. 72, no. 1 (June 1, 2008): 27–33.

Zhang, N., C. Chittasupho, C. Duangrat, T. J. Siahaan, and C. Berkland. “PLGA Nanoparticle--Peptide Conjugate Effectively Targets Intercellular Cell-Adhesion Molecule-1.” Journal Articles. Bioconjugate Chemistry 19, no. 1 (January 1, 2008): 145–152.

Zimmerman, T., J. Oyarzabal, E. S. Sebastián, S. Majumdar, B. A. Tejo, T J Siahaan, and F J Blanco. “ICAM-1 Peptide Inhibitors of T-Cell Adhesion Bind to the Allosteric Site of LFA-1. An NMR Characterization.” Journal Articles. Chem. Biol. Drug Des. 70, no. 4 (September 1, 2007): 347–353.

Majumdar, S., N. Kobayashi, J. P Krise, and T. J. Siahaan. “Mechanism of Internalization of an ICAM-1-Derived Peptide by Human Leukemic Cell Line HL-60: Influence of Physicochemical Properties on Targeted Drug Delivery.” Journal Articles. Molecular Pharmaceutics 4, no. 5 (August 1, 2007): 749–758.

Yusuf-Makagiansar, H., T. V. Yakovleva, B. A. Tejo, K. Jones, Y. Hu, G. M. Verkhivker, K. L. Audus, and T. J. Siahaan. “Sequence Recognition of Alpha-LFA-1-Derived Peptides by ICAM-1 Cell Receptors: Inhibitors of T-Cell Adhesion.” Journal Articles. Chem. Biol. Drug Des. 70, no. 3 (August 1, 2007): 237–246.

Murray, J. S., S. Oney, J. E. Page, A. Kratochvil-Stava, Y. Hu, I. T. Makagiansar, J. C. Brown, N. Kobayashi, and T. J. Siahaan. “Suppression of Type 1 Diabetes in NOD Mice by Bifunctional Peptide Inhibitor: Modulation of the Immunological Synapse Formation.” Journal Articles. Chem. Biol. Drug Des. 70, no. 3 (August 1, 2007): 227–236.

Kobayashi, N., H. Kobayashi, L. Gu, T. Malefyt, and T. J. Siahaan. “Antigen-Specific Suppression of Experimental Autoimmune Encephalomyelitis by a Novel Bifunctional Peptide Inhibitor.” Journal Articles. J. Pharmacol. Exp. Ther. 322, no. 2 (July 1, 2007): 879–886.

He, H. T., R. N. Gürsoy, L. Kupczyk-Subotkowska, J. Tian, T. D. Williams, and T. J. Siahaan. “Synthesis and Chemical Stability of a Disulfide Bond in a Model Cyclic Pentapeptide: Cyclo(1,4)-Cys-Gly-Phe-Cys-Gly-OH.” Journal Articles. J. Pharm. Sci. 95, no. 10 (September 1, 2006): 2222–2234.

Dunehoo, A. L., M. E. Anderson, S. Majumdar, N. Kobayashi, C. Berkland, and T. J. Siahaan. “Cell Adhesion Molecules for Targeted Drug Delivery.” Journal Articles. J 95, no. 9 (August 1, 2006): 1856–1872.

Anderson, M. E., B. A. Tejo, T. Yakovleva, and T. J. Siahaan. “Characterization of Binding Properties of ICAM-1 Peptides to LFA-1: Inhibitors of T-Cell Adhesion.” Journal Articles. Chem. Biol. Drug Des. 68, no. 1 (June 1, 2006): 20–28.

Kobayashi, N., A. Ikesue, S. Majumdar, and T. J. Siahaan. “Inhibition of E-Cadherin-Mediated Homotypic Adhesion of Caco-2 Cells: A Novel Evaluation Assay for Peptide Activities in Modulating Cell-Cell Adhesion.” Journal Articles. J. Pharmacol. Exp. Ther. 317, no. 1 (April 1, 2006): 309–316.

Goebel, S., M. Huang, W. C Davis, M. Jennings, T. J. Siahaan, J. S. Alexander, and C. G. Kevil. “VEGF-A Stimulation of Leukocyte Adhesion to Colonic Microvascular Endothelium: Implications for Inflammatory Bowel Disease.” Journal Articles. Am. J. Physiol.: Gastrointest. Liver Physiol. 290, no. 4 (April 1, 2006): G648–654.

Liederer, B. M., T. Fuchs, D. Vander Velde, T. J. Siahaan, and R. T. Borchardt. “Effects of Amino Acid Chirality and the Chemical Linker on the Cell Permeation Characteristics of Cyclic Prodrugs of Opioid Peptides.” Journal Articles. J. Med. Chem. 49, no. 4 (February 23, 2006): 1261–1270.

Zheng, K., M. Trivedi, and T. J. Siahaan. “Structure and Function of the Intercellular Junctions: Barrier of Paracellular Drug Delivery.” Journal Articles. Current Pharmaceutical Design 12, no. 22 (January 1, 2006): 2813–2824.

Krogmeier, S. L., D. S. Reddy, D. Vander Velde, G. H. Lushington, T. J. Siahaan, C. R. Middaugh, R. T. Borchardt, and E M Topp. “Deamidation of Model Beta-Turn Cyclic Peptides in the Solid State.” Journal Articles. J. Pharm. Sci. 94, no. 12 (November 1, 2005): 2616–2631.

Calcagno, A. M., J. M. Fostel, R. P. Orchekowski, J. T. Alston, W. B. Mattes, T. J. Siahaan, and J. A. Ware. “Modulation of Cell Adhesion Molecules in Various Epithelial Cell Lines after Treatment with PP2.” Journal Articles. Molecular Pharmaceutics 2, no. 3 (1, 2005): 170–84.

Huang, M., K. Matthews, T. J. Siahaan, and C. G. Kevil. “Alpha L-Integrin I Domain Cyclic Peptide Antagonist Selectively Inhibits T Cell Adhesion to Pancreatic Islet Microvascular Endothelium.” Journal Articles. Am. J. Physiol.: Gastrointest. Liver Physiol. 288, no. 1 (January 1, 2005): G67–73.

Wang, B., T. J. Siahaan, and R. Soltero, eds. Drug Delivery: Principles and Applications. Books. New York: John Wiley & Sons, 2005.

Calcagno, A. M., J. M. Fostel, E. L. Reyner, E. Sinaga, J. T Alston, W. B. Mattes, T. J. Siahaan, and J A Ware. “Effects of an E-Cadherin-Derived Peptide on the Gene Expression of Caco-2 Cells.” Journal Articles. Pharm. Res. 21, no. 11 (October 1, 2004): 2085–2094.

Jining, L., I. T. Makagiansar, H. Yusuf-Makagiansar, V. T Chow, T. J. Siahaan, and S. D.S. Jois. “Design, Structure and Biological Activity of Beta-Turn Peptides of CD2 Protein for Inhibition of T-Cell Adhesion.” Journal Articles. Eur. J. Biochem. 271, no. 14 (June 1, 2004): 2873–2886.

Rahman, R. N., B. A. Tejo, M. Basri, M. B. Rahman, F. Khan, S. M. Zain, T. J. Siahaan, and A B Salleh. “Reductive Alkylation of Lipase: Experimental and Molecular Modeling Approaches.” Journal Articles. Appl. Biochem. Biotech. 118, no. 1–3 (June 1, 2004): 11–20.

Stotz, C. E., R. T. Borchardt, C. R. Middaugh, T. J. Siahaan, D. Vander Velde, and E. M. Topp. “Secondary Structure of a Dynamic Type I’beta-Hairpin Peptide.” Journal Articles. Journal of Peptide Research 63, no. 4 (April 1, 2004): 371–382.

Anderson, M. E., T. Yakovleva, Y. Hu, and T. J. Siahaan. “Inhibition of ICAM-1/LFA-1-Mediated Heterotypic T-Cell Adhesion to Epithelial Cells: Design of ICAM-1 Cyclic Peptides.” Journal Articles. Bioorg. Med. Chem. Lett. 14, no. 6 (March 22, 2004): 1399–1402.

Zheng, K., I. T. Makagiansar, M. Wang, J. L. Urbauer, K. Kuczera, and T. J. Siahaan. “Expression, Purification, and Structural Study of the EC4 Domain of E-Cadherin.” Journal Articles. Prot. Express. Purif. 33, no. 1 (January 1, 2004): 72–79.

Anderson, M. E., and T. J. Siahaan. “Mechanism of Binding and Internalization of ICAM-1-Derived Cyclic Peptides by LFA-1 on the Surface of T Cells: A Potential Method for Targeted Drug Delivery.” Journal Articles. Pharm. Res. 20, no. 10 (September 1, 2003): 1523–1532.

Shuxing, Z., W. S. Ying, T. J. Siahaan, and S. D.S. Jois. “Solution Structure of a Peptide Derived from the Beta Subunit of LFA-1.” Journal Articles. Peptides 24, no. 6 (May 1, 2003): 827–35.

He, H. T., C. R. Xu, X. Song, and T. J. Siahaan. “Syntheses of Cyclic Prodrugs of RGD Peptidomimetics with Various Macrocyclic Ring Sizes: Evaluation of Physicochemical, Transport and Antithrombic Properties.” Journal Articles. Journal of Peptide Research 61, no. 6 (May 1, 2003): 331–342.

Anderson, M. E., and T. J. Siahaan. “Targeting ICAM-1/LFA-1 Interaction for Controlling Autoimmune Diseases: Designing Peptide and Small Molecule Inhibitors.” Journal Articles. Peptides 24, no. 3 (March 1, 2003): 487–501.

Jois, S. D. S., and T. J. Siahaan. “A Peptide Derived from LFA-1 That Modulates T-Cell Adhesion Binds to Soluble ICAM-1 Protein.” Journal Articles. J. Biomol. Str. Dyn. 20 (2003): 635–44.

Xu, C. R., H. T. He, X. Song, and T. J. Siahaan. “Synthesis and Comparison of Physicochemical, Transport and Antithrombic Properties of a Cyclic Prodrug and the Parent RGD Peptidomimetic.” Journal Articles. Tetrahedron 59 (2003): 2861–2869.

Makagiansar, I. T., A. Ikesue, P. D. Nguyen, J. L. Urbauer, R. J. Bieber-Urbauer, and T. J. Siahaan. “Localized Production of Human E-Cadherin-Derived First Repeat in Escherichia Coli.” Journal Articles. Protein Expr. Purif. 26, no. 3 (November 2002): 449–454.

Song, X., and T. J. Siahaan. “Synthesis and Stability Study of a Modified Phenylpropionic Acid Linker-Based Esterase-Sensitive Prodrug.” Journal Articles. Bioorg. Med. Chem. Lett. 12, no. 23 (November 2, 2002): 3439–3442.

Sinaga, E., S. D.S. Jois, M. Avery, I. T. Makagiansar, U. S.F. Tambunan, K. L. Audus, and T. J. Siahaan. “Increasing Paracellular Porosity by E-Cadherin Peptides: Discovery of Bulge and Groove Regions in the EC1-Domain of E-Cadherin.” Journal Articles. Pharm. Res. 19, no. 8 (July 1, 2002): 1170–1179.

Song, X., C. R. Xu, H. T. He, and T. J. Siahaan. “Synthesis of a Novel Cyclic Prodrug of RGD Peptidomimetic to Improve Its Cell Membrane Permeation.” Journal Articles. Bioorganic Chemistry 30, no. 4 (July 1, 2002): 285–301.

Ouyang, H., F. Tang, T. J. Siahaan, and R. T. Borchardt. “A Modified Coumarinic Acid-Based Cyclic Prodrug of an Opioid Peptide: Its Enzymatic and Chemical Stability and Cell Permeation Characteristics.” Journal Articles. Pharm. Res. 19, no. 6 (May 1, 2002): 794–801.

Makagiansar, I. T., P. D. Nguyen, A Ikesue, K. Kuczera, W. Dentler, J. L Urbauer, N. Galeva, M. Alterman, and T. J. Siahaan. “Disulfide Bond Formation Promotes the Cis- and Trans-Dimerization of the E-Cadherin-Derived First Repeat.” Journal Articles. J. Biol. Chem. 277, no. 18 (3, 2002): 16002–16010.

Makagiansar, I. T., H. Yusuf-Makagiansar, A. Ikesue, A. M. Calcagno, J. S Murray, and T. J. Siahaan. “N-Cadherin Involvement in the Heterotypic Adherence of Malignant T-Cells to Epithelia.” Journal Articles. Molecular and Cellular Biochemistry 233, no. 1–2 (April 1, 2002): 1–8.

Xu, C. R., H. Yusuf-Makagiansar, Y. Hu, S. D.S. Jois, and T. J. Siahaan. “Structural and ICAM-1-Docking Properties of a Cyclic Peptide from the I-Domain of LFA-1: An Inhibitor of ICAM-1/LFA- 1-Mediated T-Cell Adhesion.” Journal Articles. J. Biomol. Struct. Dyn. 19, no. 5 (April 1, 2002): 789–799.

Yusuf-Makagiansar, H., M. E. Anderson, T. V. Yakovleva, J. S. Murray, and T. J. Siahaan. “Inhibition of LFA-1/ICAM-1 and VLA-4/VCAM-1 as a Therapeutic Approach to Inflammation and Autoimmune Diseases.” Journal Articles. Medicinal Research Reviews 22, no. 2 (March 1, 2002): 146–167.

Murray, J. S., S. D. Fois, T. Schountz, S. R Ford, M. D. Tawde, J. C. Brown, and T. J. Siahaan. “Modeling Alternative Binding Registers of a Minimal Immunogenic Peptide on Two Class II Major Histocompatibility Complex (MHC II) Molecules Predicts Polarized T-Cell Receptor (TCR) Contact Positions.” Journal Articles. Journal of Peptide Research 59, no. 3 (March 1, 2002): 115–22.

Hu, Y., E. Webb, J. Singh, B. A. Morgan, J. A. Gainor, T. D. Gordon, and T. J. Siahaan. “Rapid Determination of Substrate Specificity of Clostridium Histolyticum Beta-Collagenase Using an Immobilized Peptide Library.” Journal Articles. J. Biol. Chem. 277, no. 10 (March 8, 2002): 8366–8371.

Ouyang, H., D. G. Vander Velde, R. T. Borchardt, and T. J. Siahaan. “Synthesis and Conformational Analysis of a Coumarinic Acid-Based Cyclic Prodrug of an Opioid Peptide with Modified Sensitivity to Esterase-Catalyzed Bioconversion.” Journal Articles. Journal of Peptide Research 59, no. 4 (March 27, 2002): 183–95.

Song, X., H. T. He, and T. J. Siahaan. “Synthesis of Cyclic Prodrugs of Aggrastat and Its Analogue with a Modified Phenylpropionic Acid Linker.” Journal Articles. Organic Letters 4, no. 4 (February 21, 2002): 549–552.

Mahadevan, J., R. Xu, T. J. Siahaan, and K. Kuczera. “Molecular Dynamics Simulations of Conformational Behavior of Linear RGD Peptidomimetics and Cyclic Prodrugs in Aqueous and Octane Solutions.” Journal Articles. J. Biomol. Struc. Dyn. 19 (2002): 775–788.

Ouyang, H., R. T. Borchardt, and T. J. Siahaan. “Steric Hindrance Is a Key Factor in the Coupling Reaction of (Acyloxy)Alkyl-α-Halides with Phenols to Make a New Promoiety for Prodrugs.” Journal Articles. Tetrahedron Lett. 43 (2002): 577–79.

Yusuf-Makagiansar, H., I. T. Makagiansar, Y. Hu, and T. J. Siahaan. “Synergistic Inhibitory Activity of Alpha- and Beta-LFA-1 Peptides on LFA-1/ICAM-1 Interaction.” Journal Articles. Peptides 22, no. 12 (November 1, 2001): 1955–1962.

Hamilton, K. O., E. Topp, I. T. Makagiansar, T. J. Siahaan, M. Yazdanian, and K. L. Audus. “Multidrug Resistance Associated Protein-1 (MRP-1) Functional Activity in Calu-3 Cells.” Journal Articles. Pharmacol. Exp. Ther. 298 (August 2001): 1199–1205.

Yusuf-Makagiansar, H., I. T. Makagiansar, and T. J. Siahaan. “Inhibition of the Adherence of T-Lymphocytes to Epithelial Cells by a Cyclic Peptide Derived from Inserted Domain of Lymphocyte Function-Associated Antigen-1.” Journal Articles. Inflammation 25, no. 3 (May 1, 2001): 203–214.

Makagiansar, I. T., M. Avery, Y. Hu, K. L. Audus, and T. J. Siahaan. “Improving the Selectivity of HAV-Peptides in Modulating E-Cadherin-E-Cadherin Interactions in the Intercellular Junction of MDCK Cell Monolayers.” Journal Articles. Pharm. Res. 18, no. 4 (April 1, 2001): 446–453.

Yusuf-Makagiansar, H., and T. J. Siahaan. “Binding and Internalization of an LFA-1-Derived Cyclic Peptide by ICAM Receptors on Activated Lymphocyte: A Potential Ligand for Drug Targeting to ICAM-1-Expressing Cells.” Journal Articles. Pharm. Res. 18, no. 3 (March 1, 2001): 329–335.

Sakaeda, T., Y. Tada, T. Sugawara, T. Ryu, F. Hirose, T. Yoshikawa, K. Hirano, et al. “Conjugation with L-Glutamate for in Vivo Brain Drug Delivery.” Journal Articles. J. Drug. Target. 9, no. 1 (2001): 23–37.

Tibbetts, S. A., S. D.S. Jois, T. J. Siahaan, S. H. Benedict, and M. A. Chan. “Linear and Cyclic LFA-1 and ICAM-1 Peptides Inhibit T Cell Adhesion and Function.” Journal Articles. Peptides 21, no. 8 (July 1, 2000): 1161–67.

Antipas, A. S., D. G. Vander Velde, S. D. S. Jois, T. J. Siahaan, and V. J. Stella. “Effect of Conformation on the Rate of Deamidation of Vancomycin in Aqueous Solutions.” Journal Articles. J. Pharm. Sci. 89 (May 2000): 742–750.

Sakaeda, T., T. J. Siahaan, K. L. Audus, and V. J. Stella. “Enhancement of Transport of D-Melphalan Analogue by Conjugation with L-Glutamate across Bovine Brain Microvessel Endothelial Cell Monolayers.” Journal Articles. J. Drug Target. 8, no. 3 (January 1, 2000): 195–204.

Jois, S. D.S., R. Hughes, and T. J. Siahaan. “Comparison of the Solution Conformations of a Cell-Adhesive Peptide LBE and Its Reverse Sequence EBL.” Journal Articles. J. Biomol. Struct. Dyn. 17, no. 3 (November 1, 1999): 429–444.

Tibbetts, S. A., C. Chirathaworn, M. Nakashima, S. D.S. Jois, T. J. Siahaan, M. A. Chan, and S. H. Benedict. “Peptides Derived from ICAM-1 and LFA-1 Modulate T Cell Adhesion and Immune Function in a Mixed Lymphocyte Culture.” Journal Articles. Transplantation 68, no. 5 (August 15, 1999): 685–692.

Bogdanowich-Knipp, S. J., S. D.S. Jois, and T. J. Siahaan. “Effect of Conformation on the Conversion of Cyclo-(1,7)-Gly-Arg-Gly-Asp-Ser-Pro-Asp-Gly-OH to Its Cyclic Imide Degradation Product.” Journal Articles. Journal of Peptide Research 54, no. 1 (June 1, 1999): 43–53.

Bogdanowich-Knipp, S. J., S. Chakrabarti, T. D. Williams, R. K. Dillman, and T. J. Siahaan. “Solution Stability of Linear vs. Cyclic RGD Peptides.” Journal Articles. Journal of Peptide Research 53, no. 5 (1, 1999): 530–541.

Bogdanowich-Knipp, S. J., S. D.S. Jois, and T. J. Siahaan. “The Effect of Conformation on the Solution Stability of Linear vs. Cyclic RGD Peptides.” Journal Articles. Journal of Peptide Research 53, no. 5 (1, 1999): 523–529.

Gürsoy, R. N., and T. J. Siahaan. “Binding and Internalization of an ICAM-1 Peptide by the Surface Receptors of T Cells.” Journal Articles. Journal of Peptide Research 53, no. 4 (April 1, 1999): 414–421.

Gürsoy, R. N., S. D.S. Jois, and T. J. Siahaan. “Structural Recognition of an ICAM-1 Peptide by Its Receptor on the Surface of T Cells: Conformational Studies of Cyclo (1, 12)-Pen-Pro-Arg-Gly-Gly-Ser-Val-Leu-Val-Thr-Gly-Cys-OH.” Journal Articles. Journal of Peptide Research 53, no. 4 (April 1, 1999): 422–431.

Bak, A., T. J. Siahaan, O. S. Gudmundsson, S. Gangwar, G. J. Friis, and R. T. Borchardt. “Synthesis and Evaluation of the Physicochemical Properties of Esterase-Sensitive Cyclic Prodrugs of Opioid Peptides Using an (Acyloxy)Alkoxy Linker.” Journal Articles. Journal of Peptide Research 53, no. 4 (April 1, 1999): 393–402.

Gudmundsson, O. S., D. G. Vander Velde, S. D. Jois, A. Bak, T. J. Siahaan, and R. T. Borchardt. “The Effect of Conformation of the Acyloxyalkoxy-Based Cyclic Prodrugs of Opioid Peptides on Their Membrane Permeability.” Journal Articles. Journal of Peptide Research 53, no. 4 (April 1, 1999): 403–413.

Gudmundsson, O. S., S. D.S. Jois, D. G. Vander Velde, T. J. Siahaan, B. Wang, and R. T. Borchardt. “The Effect of Conformation on the Membrane Permeation of Coumarinic Acid- and Phenylpropionic Acid-Based Cyclic Prodrugs of Opioid Peptides.” Journal Articles. Journal of Peptide Research 53, no. 4 (April 1, 1999): 383–392.

Jois, S. D.S., S. A. Tibbetts, M. A. Chan, S. H. Benedict, and T. J. Siahaan. “A Ca2+ Binding Cyclic Peptide Derived from the Alpha-Subunit of LFA-1: Inhibitor of ICAM-1/LFA-1-Mediated T-Cell Adhesion.” Journal Articles. Journal of Peptide Research 53, no. 1 (January 1, 1999): 18–29.

Bak, A., O. S. Gudmundsson, G. J. Friis, T. J. Siahaan, and R. T. Borchardt. “Acyloxyalkoxy-Based Cyclic Prodrugs of Opioid Peptides: Evaluation of the Chemical and Enzymatic Stability as Well as Their Transport Properties across Caco-2 Cell Monolayers.” Journal Articles. Pharm. Res. 16, no. 1 (January 1, 1999): 24–29.

Gudmundsson, O. S., K. Nimkar, S. Gangwar, T. J. Siahaan, and R. T. Borchardt. “Phenylpropionic Acid-Based Cyclic Products of Opioid Peptides That Exhibit Metabolic Stability to Peptidases and Excellent Cellular Permeation.” Journal Articles. Pharm. Res. 16 (1999): 16–23.

Wang, B., K. Nimkar, W. Wang, H. Zhang, D. Shan, O. S. Gudmundsson, S. Gangwar, T. J. Siahaan, and R. T. Borchardt. “Synthesis and Evaluation of the Physicochemical Properties of Esterase-Sensitive Cyclic Prodrugs of Opioid Peptides Using Coumarinic Acid and Phenylpropionic Acid Linkers.” Journal Articles. J. Pept. Res. 53 (1999): 370–382.

Gangwar, S., G. M. Pauletti, T. J. Siahaan, V. J. Stella, and R. T. Borchardt. “Synthesis of an Esterase-Sensitive Cyclic Prodrug of a Model Hexapeptide Having Enhanced Membrane Permeability and Enzymatic Stability Using an Acyloxyalkoxy Promoiety.” Journal Articles. Meth. Mol. Med. 23 (January 1, 1999): 37–51.

Knipp, G. T., D. G. Vander Velde, T. J. Siahaan, and R. T. Borchardt. “The Effect of Beta-Turn Structure on the Passive Diffusion of Peptides across Caco-2 Cell Monolayers.” Journal Articles. Pharm. Res. 14, no. 10 (September 1, 1997): 1332–1340.

Pauletti, G. M., S. Gangwar, T. J. Siahaan, J. Aube, and R. T. Borchardt. “Improvement of Oral Peptide Bioavailability: Peptide Mimetics and Prodrug Strategies.” Journal Articles. Adv. Drug Del. Rev. 27 (August 15, 1997): 235–256.

Pauletti, G. M., S. Gangwar, T. J. Siahaan, J. Aubé, and R. Borchardt. “Improvement of Oral Peptide Bioavailability: Peptidomimetics and Prodrug Strategies.” Journal Articles. Adv. Drug Del. Rev. 27, no. 2–3 (August 15, 1997): 235–256.

Lutz, K. L., and T. J. Siahaan. “Molecular Structure of the Apical Junction Complex and Its Contribution to the Paracellular Barrier.” Journal Articles. J. Pharm. Sci. 86, no. 9 (August 1997): 977–984.

Jois, D. S., D. Pal, S. A. Tibbetts, M. A. Chan, S. H. Benedict, and T. J. Siahaan. “Inhibition of Homotypic Adhesion of T-Cells: Secondary Structure of an ICAM-1-Derived Cyclic Peptide.” Journal Articles. Journal of Peptide Research 49, no. 6 (May 1, 1997): 517–526.

Hühmer, A. F., G. I. Aced, M. D. Perkins, R. N. Gürsoy, D. S. Jois, C. Larive, T. J. Siahaan, and C. Schôneich. “Separation and Analysis of Peptides and Proteins.” Journal Articles. Analytical Chemistry 69, no. 12 (May 15, 1997): 29R–57R.

Kupczyk-Subotkowska, L., T. J. Siahaan, A. S. Basile, H. S. Friedman, P. E. Higgins, D. Song, and J. M. Gallo. “Modulation of Melphalan Resistance in Glioma Cells with a Peripheral Benzodiazepine Receptor Ligand-Melphalan Conjugate.” Journal Articles. J. Med. Chem. 40, no. 11 (23, 1997): 1726–1730.

Lutz, K. L., and T. J. Siahaan. “Modulation of the Cellular Junctions Protein E-Cadherin in Bovine Brain Microvessel Endothelial Cells by Cadherin Peptides.” Journal Articles. Drug Delivery 10 (March 28, 1997): 187–193.

Gangwar, S., G. M. Pauletti, T. J. Siahaan, V. J. Stella, and R. T. Borchardt. “Synthesis of a Novel Esterase-Sensitive Cyclic Prodrug of a Hexapeptide Using an Acyloxyalkoxy Promoiety.” Journal Articles. J. Org. Chem. 62 (March 7, 1997): 1356–1362.

Wang, B., S. Gangwar, G. M. Pauletti, T. J. Siahaan, and R. T. Borchardt. “Synthesis of a Novel Esterase-Sensitive Cyclic Prodrug System for Peptides That Utilizes a ‘Trimethyl Lock’-Facilitated Lactonization Reaction.” Journal Articles. J. Org. Chem. 62 (March 7, 1997): 1363–1367.

Okumu, F. W., G. M. Pauletti, D. G. Vander Velde, T. J. Siahaan, and R. T. Borchardt. “Effect of Restricted Conformational Flexibility on the Permeation of Model Hexapeptides across Caco-2 Cell Monolayers.” Journal Articles. Pharm. Res. 14, no. 2 (February 1, 1997): 169–175.

Jois, D. S., M. W. Conrad, S. Chakrabarti, and T. J. Siahaan. “Conformational Analysis of Cyclo(2,9)-Ac-QCRSVEGSCG-OH from the C-Terminal Loop of Human Growth Hormone.” Journal Articles. The Journal of Peptide Research : Official Journal of the American Peptide Society 49, no. 1 (January 1, 1997): 15–22.

Kupczyk-Subotkowska, L., K. Tamura, D. Pal, T. Sakaeda, T. J. Siahaan, V. J. Stella, and R. T. Borchardt. “Derivatives of Melphalan Designed to Enhance Drug Accumulation in Cancer Cells.” Journal Articles. J. Drug Targeting 4, no. 6 (1997): 359–370.

Pal, D. J., K. L. Audus, and T. J. Siahaan. “Modulation of Cellular Adhesion in Bovine Brain Microvessel Endothelial Cells by a Decapeptide.” Journal Articles. Brain Research 747, no. 1 (January 30, 1997): 103–113.

Gangwar, S., G. M. Pauletti, B. Wang, T. J. Siahaan, V. J. Stella, and R. T. Borchardt. “Prodrug Strategies to Enhance the Intestinal Absorption of Peptides.” Journal Articles. Drug Discovery Today 2 (1997): 148–155.

Pauletti, G. M., S. Gangwar, F. W. Okumu, T. J. Siahaan, V. J. Stella, and R. T. Borchardt. “Esterase-Sensitive Cyclic Prodrugs of Peptides: Evaluation of an Acyloxyalkoxy Promoiety in a Model Hexapeptide.” Journal Articles. Pharm. Res. 13, no. 11 (October 1, 1996): 1615–1623.

Gangwar, S., S. D.S. Jois, T. J. Siahaan, D. G. Vander Velde, V. J. Stella, and R. T. Borchardt. “The Effect of Conformation on Membrane Permeability of an Acyloxyalkoxy-Linked Cyclic Prodrug of a Model Hexapeptide.” Journal Articles. Pharm. Res. 13, no. 11 (October 1, 1996): 1657–1662.

Lutz, K. L., L. A. Szabo, D. L. Thompson, and T. J. Siahaan. “Antibody Recognition of Peptide Sequences from the Cell-Cell Adhesion Proteins: N- and E-Cadherins.” Journal Articles. Peptide Research 9, no. 5 (August 1, 1996): 233–239.

Jois, S. D.S., U. S.F. Tambunan, S. Chakrabarti, and T. J. Siahaan. “Solution Structure of a Cyclic RGD Peptide That Inhibits Platelet Aggregation.” Journal Articles. J. Biomol. Struct. Dyn. 14, no. 1 (July 1, 1996): 1–11.

Pauletti, G. M., S. Gangwar, G. T. Knipp, M. M. Nerurkar, F. W. Okumu, K. Tamura, T. J. Siahaan, and R. T. Borchardt. “Structural Requirements for Intestinal Absorption of Peptide Drugs.” Journal Articles. J. Control. Rel. 41 (July 1996): 3–17.

Lutz, K. L., S. D.S. Jois, and T. J. Siahaan. “Secondary Structure of the HAV Peptide Which Regulates Cadherin-Cadherin Interaction.” Journal Articles. J. Biomol. Struct. Dyn. 13, no. 3 (July 17, 1995): 447–455.

Lutz, K. L., and T. J. Siahaan. “E-Cadherin Peptide Sequence Recognition by Anti-E-Cadherin Antibody.” Journal Articles. Biochem. Biophys. Res. Commun. 211, no. 1 (May 6, 1995): 21–27.

Schöneich, C., A. F. R. Hühmer, S. R. Rabel, J. F. Stobaugh, S. D. S. Jois, C. K. Larive, T. J. Siahaan, T. C. Squier, D. J. Bigelow, and T. D. Williams. “Separation and Analysis of Peptides and Proteins.” Journal Articles. Anal. Chem. 67 (May 1995): 155R–181R.

Oliyai, R., T. J. Siahaan, and V. J. Stella. “The Importance of Structural Factors on the Rate and the Extent of N,O-Acyl Migration in Cyclic and Linear Peptides.” Journal Articles. Pharm. Res. 12, no. 3 (March 1, 1995): 323–328.

Siahaan, T. J., D. Bruss, N. A. Powell, S. Chakrabarti, and M. Conrad. “The Aqueous Conformation of Cyclo(1,6)Ac-Cys-Arg-Gly-Asp-Phe-Pen-NH2.” Journal Articles. Int. J. Pept. Prot. Res. 44, no. 5 (October 1, 1994): 427–434.

Siahaan, T. J., and K. Lutz. “Conformational Study of Cyclo[Gln-Trp-Phe-Gly-Leu-Met] as NK-2 Antagonist by NMR and Molecular Dynamics.” Journal Articles. J. Pharm. Biomed. Analysis 12, no. 1 (January 1, 1994): 65–71.

Siahaan, T. J., S. Chakrabarti, and D. Vander Velde. “Conformational Study of Cyclo(1,5)-Ac-Pen-Arg-Gly-Asp-Cys-NH2 in Water by NMR and Molecular Dynamics.” Journal Articles. Biochemical and Biophysical Research Communications 187, no. 2 (August 16, 1992): 1042–1047.

Barry, C. E., III, R. B. Bates, W. A. Beavers, F. A. Camou, B. Gordon III, H. F.-J. Hsu, N. S. Mills, et al. “Delocalized Carbanion in Synthesis.” Journal Articles. Synlett. 4 (1991): 207–212.

Lipshutz, B. H., B. E. Huff, K. E. McCarthy, T. A. Miller, S. M. Jaweed Mukarram, T. J. Siahaan, W. D. Vaccaro, H. Webb, and A. M. Falick. “Oxazolophanes as Masked Cyclopeptide Alkaloid Equivalents: Cyclic Peptide Chemistry without Peptide Couplings.” Journal Articles. J. Am. Chem. Soc. 112 (August 1990): 7032–7041.

Bates, R. B., T. J. Siahaan, and K. Suvannachut. “A New Rearrangement of Alkoxybenzyl Anions.” Journal Articles. J. Org. Chem. 55 (1990): 1328–1334.

Lipshutz, B. H., E. L. Ellsworth, and T. J. Siahaan. “The Role of BF3.Et2O in Reactions of Lower Order (Gilman) Organocuprates.” Journal Articles. J. Am. Chem. Soc. 111 (February 1989): 1351–1358.

Tsonis, P. A., V. Carperos, and T. J. Siahaan. “Modeling of the Homoeo Domain Suggests Similar Structure to Repressors.” Journal Articles. Biochemical and Biophysical Research Communications 157, no. 1 (October 30, 1988): 100–105.

Lipshutz, B. H., E. L. Ellsworth, and T. J. Siahaan. “Effects of BF3.Et2O on Higher Order Organocuprate Reactions: Substrate Activation or Cuprate Modification?” Journal Articles. J. Am. Chem. Soc. 110 (June 1988): 4834–4835.

Jolad, S. D., B. N. Timmermann, J. J. Hoffmann, R. B. Bates, F. A. Camou, and T. J. Siahaan. “Grindelane Diterpenoids from Isocoma Tenuisecta.” Journal Articles. Phytochem. 27, no. 2 (1988): 497–499.

Jolad, S. D., B. N. Timmermann, J. J. Hoffmann, R. B. Bates, F. A. Camou, and T. J. Siahaan. “Kolavane Diterpenoids of Vanclevae Stylosa.” Journal Articles. Phytochem. 27, no. 2 (1988): 505–515.

Jolad, S. D., B. N. Timmernann, J. J. Hoffmann, R. B. Bates, F A. Camou, and T. J. Siahaan. “Sesquiterpenoid Glycosides and an Acetogenin Glucoside from Lessingia Glandulifera.” Journal Articles. Phytochemistry 27, no. 7 (1988): 2199–2204.

Lipshutz, B. H., E. L. Ellsworth, T. J. Siahaan, and A. Shirazi. “Unexpected Affects of Me3Si-X on Reactions of Higher Order Cyanocuprates.” Journal Articles. Tetrahedron Lett. 29 (1988): 6677–6680.

Bates, R. B., T. J. Siahaan, K. Suvannachut, S. K. Vasey, and K. M. Yager. “Preparation and Reactions of Trianions from the Dimethylphenols.” Journal Articles. J. Org. Chem. 52 (September 1, 1987): 4605–4608.

Hoffmann, J. J., S. D. Jolad, B. N. Timmermann, R. B. Bates, F. A. Camou, and T. J. Siahaan. “A New Diterpenoid from Ericameria Laricifolia.” Journal Articles. Phytochem. 26 (1987): 2861–2863.

Sardesai, L. G., S. K. Paknikar, R. B. Bates, T. J. Siahaan, V. V. Kane, and P. K. Mishra. “A New Heterocyclic System from Salol and Phenylacetic Acid.” Journal Articles. Heterocycles 26 (1987): 2941–2944.

Timmermann, B. N., J. J. Hoffmann, S. D. Jolad, R. B. Bates, and T. J. Siahaan. “Five Grindelane Diterpenoids from Grindelia Acutifolia.” Journal Articles. Phytochem. 26 (1987): 467–470.

Jolad, S. D., B. N. Timmermann, J. J. Hoffmann, R. B. Bates, and T. J. Siahaan. “Havardic Acids A-F, and Havardiol, Labdane Diterpenoids from Grindelia Havardii.” Journal Articles. Phytochem. 26 (1987): 483–89.

Bates, R. B., S. A. Roberts, T. J. Siahaan, T. Gnanasambandan, and S. H. Yalkowsky. “9,10-Anthracenedicarbaldehyde Bis[(4,5-Dihydro-1H-Imidazol-2-Yl)Hydrazone] Acetic Acid Hydrochloric Acid Trihydrate Salt (Bisantrene).” Journal Articles. Acta Cryst. C42 (1986): 186–188.

Jolad, J. D., R. B. Bates, J. R. Cole, J. J. Hoffmann, T. J. Siahaan, and B. N. Timmermann. “Cardenolides and a Lignan from Asclepias Subulata.” Journal Articles. Phytochem. 25 (1986): 2581–2590.

Timmermann, B. N., J. J. Hoffmann, S. D. Jolad, R. B. Bates, and T. J. Siahaan. “Labdane Diterpenoids from Grindelia Discoidea (Asteraceae).” Journal Articles. Phytochem. 25 (1986): 1389–1392.

Awards & Honors —

2014 PhRMA Foundation Award in Excellence in Pharmaceutics

PhRMA Foundation, USA

2014

2013 Mentor of the Year

Office for Diversity in Science Training, The University of Kansas

2013

J Clarence Karcher Lecturer

University of Oklahoma

2005

Research Scholar Award

Pfizer

2002 - 2005

Madison and Lila Self Faculty Scholar

University of Kansas

2001 - 2004

2002 Eurand Award, Honorable Mention

Controlled Release Society

2002

Clark W. Smith Fellowship

The University of Arizona

1985

Department of Chemistry Fellowship

The University of Arizona

1984

Fellow of the American Association of Pharmaceutical Scientists

American Association of Pharmaceutical Scientists

2002 - Present

Service —

Dr. Siahaan serves as an Associate Chair of Pharmaceutical Chemistry Department; a member of the School of Pharmacy Executive Committee; a member of the Steering committee of NIH IRACDA Training Program; a member of Board of Director and Vice Chair of Globalization of Pharmaceutics Education Network; an editorial board member of Scientific Journals (i.e., Medicinal Research Reviews, Pharmaceutical Research, American Journal of Clinical and Experimental Immunology, and Medicinal Chemistry); a reviewer Granting Agencies (i.e., National Institutes of Health, Alzheimer’s Association, National MS Society).